KingAgroot Synthesis Center has a high level compound creation team, mainly studies new herbicide discovery & synthesis and process chemistry (technique research).
The synthesis center dedicates to designing and synthesizing of new compounds. After screening out compounds with herbicide activity in bioassay center, then the synthesis center will modify and derive the structure to obtain new herbicides with better selectivity, high efficiency, low toxicity and less persistence.
With mature organic synthesis platforms and the introduction of world-class microtube reactor, the synthesis center can better play its team advantage and greatly improve scientific research efficiency. The synthesis center will continuously provide innovation energy for KingAgroot.
Up to now, KingAgroot Synthesis Center has successfully created 4 novel compounds with both commercial and social values, which are Cypyrafluone（环吡氟草酮），Bipyrazone（双唑草酮）, Tripyrasulfone（三唑磺草酮） and Fenpyrazone（苯唑氟草酮）. The synthesis center has large quantities of compound resources and large amounts of compounds are added to the compound library every year. These compounds are the basic resources to solve resistant weed problems in terms of creating herbicides with new modes of action.
KingAgroot Molecular Center dedicates to gene editing breeding and weed resistance molecular biological mechanism studying. Under the leadership of Doc. Li Huarong, KingAgroot is one of the earliest pesticide companies that owns this research program.
The molecular center established a mature and complete molecular operation platform which is equipped with PCR instrument, ultracentrifuge, low-temperature refrigeration system, gel-imaging system, aseptic operation system, biochemical incubating system, illumination incubating system, etc.
On the basis of detailed analysis of resistant genes, KingAgroot expects to solve the increasingly serious resistant weed problems through CRISPR gene edited non-transgenic breeding and RNAi techniques.
Up to now, the molecular center has found several key functional genes in wheat, corn, rice, etc. These genes will be modified to realize herbicide-, insect- and disease-resistance of crops, laying a good foundation for the full commercialization.
KingAgroot Bioassay Center has the most competitive weed resistance research team in China， mainly working on the research of weed resistance as well as evaluation & screening of new compounds.
KingAgroot Bioassay Center is equipped with the biggest modern bioassay greenhouse, which covers an usable area of 2,000 square meters (in 2019, the greenhouse will be expanded to 12,000 square meters). The greenhouse has annual screening capacity of thousands of compounds.
The bioassay center consists of a resistant weed seed bank (which contains abundant weed seeds), large phytotrons, illumination incubator rooms, spray tower rooms and analysis rooms, which provides effective guarantee for relative studies to develop smoothly. Every year one or two cases of new compounds are promoted to field trial stage in this center.
The bioassay center collects suspected resistant weed seeds from every main producing areas of rice and wheat across the country every year. There are two low temperature germplasm resources repository in this center, storing ten thousands of resistant weed biotypes, ranking first in China even Asia in terms of resistant weed germplasm resource storage.
KingAgroot Formulation Center mainly conducts formulation research, structural analysis & measurement and assists the synthesis center in doing process tracking, material identification and crystal structure research. The center pays close attention to the formulation study of OD (one of the pesticide formulations).
As an important link in the cooperative research of different centers, the formulation center is equipped with many analytical instruments, such as LC, GC, PC, LC-MS,GC-MS, etc. to meet the demand of precision researches like ultra-low volume composition analysis, purification, preparation, micro/trace determination, etc.
KingAgroot is optimistic about the future development of aerial application.The herbicide can be directly used by drones and do not need other adjuvants during the aerial application. KingAgroot’s OD products are finely-ground particles with superfine particle size (the D50 is about 1μm and the D90 is less than 3μm), so the atomization effect is very good and the droplet size is appropriate. To meet different requirements for water quality in production practices in various regions, we have added many high grade adjuvants to different formulations and conducted very strict emulsifying dilution operations.
The main job of KingAgroot Precision Agriculture’s data engineer team is data development and utilization of weed resistance, so as to serve the precise management of resistant weeds under the framework of precision agriculture.
Data collection & analysis system: collecting related information of geographical location, weather-climate, land area and soil conditions to obtain comprehensive resistance data of different weeds through various ways such as weed resistance feedback of large holders, resistance surveys conducted by sales team, resistance research of R&D system, etc. and finally generalizing all the information into a full weed resistance data bank including information of every farm land.
Weed recognition system: with the application of deep network neural recognition technology in image identification field, the system can repeatedly analyze and recognize similar targets and automatically raise questions and give answers through computer weak supervised deep learning.
Chemists’ creative note-taking application: the precision agriculture team developed the first mobile chemical structure editing software KingDraw which is freely available for global users. Chemists may save their creativity and inspiration anytime and anywhere to promote creation efficiency of novel compounds.
Research and development is the belief of everyone in KingAgroot. In terms of compound invention, KingAgroot’s innovation team has successfully developed 4 HPPD inhibitors: Cypyrafluone(环吡氟草酮),Bipyrazone(双唑草酮), Tripyrasulfone(三唑磺草酮) and Fenpyrazone(苯唑氟草酮). By the end of July 2019, KingAgroot has filed 108 national invention patents (including 32 authorized ones) and 84 PCT patents (including 4 authorized ones), accumulatively entering 79 country (region)-time.
Six products containing active ingredients of Cypyrafluone(环吡氟草酮) and Bipyrazone(双唑草酮) have been officially authorized by Ministry of Agriculture and Rural Affairs of the People’s Republic of China. The registration numbers are PD20184016 (10% Bipyrazone(双唑草酮) OD), PD20184017(22%fluroxypyr+Bipyrazone(双唑草酮) OD), PD20184018（96% Bipyrazone（双唑草酮), TC), PD20184019（6% Cypyrafluone（环吡氟草酮) OD）, PD20184020（25% Cypyrafluone（环吡氟草酮）+isoproturon）, PD20184021（95% Cypyrafluone（环吡氟草酮） TC）, respectively.
Bipyrazone(双唑草酮)is an brand-new HPPD inhibitor independently invented by KingAgroot. It is the first HPPD inhibitor used to control grasses in wheat and has no cross-resistance. The innovation and application of Cypyrafluone(环吡氟草酮) is of significance in the wheat herbicide history.
Bipyrazone(双唑草酮)is a brand-new HPPD inhibitor invented by KingAgroot. It is safe to wheat and can be used to control resistant and multi-resistant broadleaf weeds like Descurainia Sophia (播娘蒿), Capsella bursa-pastoris (荠菜), Sinapis arvensis (野油菜), Stellaria media (繁缕), Malachium aquaticum (牛繁缕), Buglossoides arvense (麦家公), Lamium amplexicaule (宝盖草), Galium aparine (猪殃殃), Lamium amplexicaule (宝盖草), etc. It has no cross-resistance.
Fenpyrazone(苯唑氟草酮) is the latest compound in the HPPD inhibitor family invented by KingAgroot. With no cross-resistance, Fenpyrazone(苯唑氟草酮) is probably the best management program for ALS-inhibitor resistant weeds in corn. It has good corn selectivity and following crop flexibility as well as broader grass spectrum.
Tripyrasulfone(三唑磺草酮)is a brand-new HPPD-inhibitor invented by KingAgroot, which is first used as post-emergence spray treatment to control grass weeds in rice. With no cross-resistance, it is regarded as top solution for multi-resistant Echinochloa (稗草) and Leptochloa (千金子).